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pentobarbital will lessen the level or effect of buprenorphine, extensive-performing injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Clients who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers needs to be monitored to make c